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KMID : 0043320110340122007
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Archives of Pharmacal Research
2011 Volume.34 No. 12 p.2007 ~ p.2014
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Chemical constituents from the aerial parts of Isodon coetsa and their cytotoxicity
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Zhao Wei
Pu Jian Xin
Du Xue
Wu Ying Li
Zhao Yong
He Fei
Zhang Hai Bo
Xue Yong Bo
Xiao Wei Lie
Chen Guo Qiang
Sun Han Dong
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Abstract
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Three new compounds (1?3), including a neolignan, a triterpenoid, and a diterpenoid, together with twenty known compounds (4?23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data. Compounds 1, 3, 5?9, 11?13, 16?17, and 19?23 were evaluated for their cytotoxicity against HT-29, BEL-7402, and SK-OV-3 human tumor cell lines. Compound 7 showed significant inhibitory effects on all three types of cells, with IC50 values of 2.52, 3.06, 2.14 μM, respectively.
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KEYWORD
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Neolignan, Triterpenoid, Diterpenoid, Isodon coetsa, Cytotoxicity, Human tumor cell lines
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